If you are suffering from depression or anxiety and are trying to find a viable option for treatment, there are a lot of drugs that can help. Lexapro is one of the most commonly used drugs to treat anxiety and depression, but many people now choose to take Wellbutrin instead.

So, what is the difference between Wellbutrin vs Lexapro? We’re here to clear up the confusion.

Keep reading below to learn more about these two medications and which one might be better for you.

What is Wellbutrin (Bupropion)?

Wellbutrin, also known as Bupropion, is a type of antidepressant that works by increasing the levels of dopamine and norepinephrine in the brain. This can help improve mood, motivation, and energy levels.

It is important to talk to a healthcare professional about your options for anxiety medication. This is to determine which one is the best fit for your individual needs.

What is Lexapro (Escitalopram)?

Lexapro, also known as escitalopram, is specifically designed to treat anxiety disorders. This includes generalized anxiety disorder and panic disorder. It works by increasing the levels of the neurotransmitter serotonin in the brain.

Both medications have potential side effects and interactions. It’s important to discuss your options with a healthcare provider before starting treatment.

Comparing Wellbutrin and Lexapro

Wellbutrin vs Lexapro

Medications like Wellbutrin and Lexapro can help with anxiety. Both of these medications are often used to treat anxiety, but there are some key differences between them that can help you decide which one to take. Read on to learn more.

Mechanism of Action

Wellbutrin and Lexapro are both commonly prescribed medications for the treatment of anxiety. While they both fall under the category of antidepressants, they have different mechanisms of action. Wellbutrin works by increasing the levels of:

  • dopamine
  • norepinephrine
  • serotonin

These are neurotransmitters that regulate mood and emotions. On the other hand, Lexapro primarily acts on serotonin alone by blocking its reabsorption in the brain. Because the way these drugs work is different, they can have different effects on different people. It’s important to talk to a doctor to find out which drug might be best for your needs.

In the end, knowing how Wellbutrin and Lexapro work can help people choose the best anxiety medication for them.

Side Effects

Like all medications, these drugs come with potential side effects. Wellbutrin may cause:

  • insomnia
  • dry mouth
  • headaches

Lexapro may cause nausea, weight gain, and sexual dysfunction. It is important to discuss with your doctor the potential side effects of each medication and determine which one is the best fit for you.

Risk of Withdrawal

When it comes to treating anxiety, doctors often prescribe drugs like Wellbutrin and Lexapro. However, it is important to note that both of these medications carry a risk of withdrawal symptoms if stopped abruptly.

Wellbutrin is known to cause withdrawal symptoms such as headaches, nausea, and irritability. Lexapro may cause symptoms such as dizziness, flu-like symptoms, and fatigue. It is best to slowly stop taking both of these drugs so that you don’t have withdrawal symptoms.

Talking to a doctor is the best way to decide which medicine is best for you and to make a plan for safely stopping the medicine if you need to.


It is important to understand the differences between these two medications. As well as any potential contraindications that may exist. Wellbutrin and Lexapro both change the levels of neurotransmitters in the brain, but they do so in different ways.

While Wellbutrin primarily affects dopamine and norepinephrine, Lexapro focuses on serotonin. This means that individuals who have a history of seizures or eating disorders may be better suited for Lexapro. While those with high blood pressure or a history of drug abuse may need to avoid Wellbutrin due to potential contraindications,

It is crucial to consult with a healthcare provider. This helps to determine the best medication option for you and to monitor for any potential adverse reactions.

Which one is right for you?

If your doctor has told you that you have generalized anxiety disorder or major depressive disorder, Lexapro may be the best choice. However, if your anxiety is secondary to depression, they may give you Wellbutrin instead.

When choosing between these two drugs, it’s important to think about how well you can handle possible side effects. If you’re concerned about sexual side effects, Wellbutrin may be preferred. Whereas if you’re more worried about weight gain, Lexapro may be a better choice.

Your doctor will also look at your medical history, including any other medicines you may be taking. This is to determine the best treatment option for you.

Keep in mind that individual responses to medication can vary widely. It may take some trial and error to find the most effective treatment for your anxiety.

Alternate Treatment

When it comes to treating anxiety, there are various medication options available. This includes the following:

Therapy and Counseling

There are several effective therapies available for the treatment of anxiety. One such therapy is cognitive-behavioral therapy (CBT), which is widely recognized and based on evidence.

This anxiety treatment focuses on identifying and modifying negative thought patterns and behaviours that contribute to anxiety. Through this process, a trained therapist can guide individuals toward reducing anxiety. There are other three effective ways to manage anxiety:

  • Exposure Therapy
  • Mindfulness-based therapies
  • Talk Therapy

These approaches can help individuals confront and desensitize themselves to anxiety triggers, stay present in the moment, and gain valuable insights and coping strategies through speaking with a trained therapist or counselor.

Lifestyle Changes

In order to support your mental wellness and reduce anxiety, there are several lifestyle factors that you can focus on. Firstly, regular physical activity has been shown to release endorphins, improve sleep, and reduce stress hormones. Secondly, a balanced diet rich in fruits, vegetables, whole grains, and omega-3 fatty acids can also support overall mental health.

To manage anxiety, avoid excessive caffeine and alcohol, prioritize good sleep hygiene, and incorporate stress-reduction techniques like deep breathing, progressive muscle relaxation, and meditation into your daily routine.

A Guide Between Wellbutrin vs Lexapro

In conclusion, when considering treatment options for anxiety, it is important to weigh the pros and cons of both Wellbutrin vs Lexapro. While both medications are effective in managing symptoms, they have different mechanisms and potential side effects.

Consult with a doctor or mental health professional to determine the best fit for your individual needs. Remember, taking steps toward managing your anxiety is crucial for your overall well-being. 

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